Journal
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
Volume 91, Issue 5, Pages 335-337Publisher
KARGER
DOI: 10.1159/000350025
Keywords
Transient global amnesia; Hippocampus; Deep brain stimulation; Globus pallidus internus; Dystonia
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We report on a 66-year-old woman with segmental dystonia treated with chronic bilateral deep brain stimulation of the globus pallidus internus, in whom accidental high-voltage, high-frequency stimulation induced an episode of transient global amnesia (TGA) via an electrode contact which was misplaced in the right hippocampus. A possible mechanism underlying this TGA episode may have been the inhibition of local neuronal activity or fiber activation by high current density via direct electrical stimulation of hippocampal structures. While a unifying etiology of TGA has not been proven so far, our case demonstrates a possible link between focal electrical stimulation of hippocampal structures and the full clinical picture of the syndrome. Copyright (C) 2013 S. Karger AG, Basel
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