Journal
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
Volume 87, Issue 4, Pages 256-265Publisher
KARGER
DOI: 10.1159/000225979
Keywords
Deep brain stimulation; Schizophrenia; Neurostimulation; Hippocampus; Nucleus accumbens; Dopamine; Psychosis
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Funding
- Howard Hughes Medical Institute R
- PHS [P01 NS048120]
- Paul Janssen Fellowship for Translational Neuroscience
- The Neuroresearch Award (Boston Scientific)
- NATIONAL INSTITUTE OF MENTAL HEALTH [T32MH020004] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS048120] Funding Source: NIH RePORTER
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Schizophrenia is a chronic and disabling psychiatric illness that is often refractory to treatment. Psychotic symptoms (e. g. hallucinations and delusions) in schizophrenia are reliably correlated with excess dopamine levels in the striatum, and have more recently been related to excess metabolic activity in the hippocampus. Multiple lines of evidence suggest that aberrantly high hippocampal activity may, via hippocampal connections with the limbic basal ganglia, drive excessive dopamine release into the striatum. In the present paper, we hypothesize that inhibition or stabilization of neural activity with high-frequency electrical stimulation of the hippocampus or nucleus accumbens, through different mechanisms, would treat the positive symptoms of schizophrenia. Thus, we suggest a direction for further experimentation aimed at developing neurosurgical therapeutic approaches for this devastating disease. Copyright (C) 2009 S. Karger AG, Basel
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