Journal
STEM CELLS AND DEVELOPMENT
Volume 21, Issue 4, Pages 513-520Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/scd.2011.0526
Keywords
-
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP-Sao Paulo, Brazil)
- Conselho Nacional de Pesquisa (CNPq-Brasilia, Brazil)
Ask authors/readers for more resources
Autophagy is a lysosome-dependent degradation pathway that allows cells to recycle damaged or superfluous cytoplasmic content, such as proteins, organelles, and lipids. As a consequence of autophagy, the cells generate metabolic precursors for macromolecular biosynthesis or ATP generation. Deficiencies in this pathway were associated to several pathological conditions, such as neurodegenerative and cardiac diseases, cancer, and aging. The aim of this review is to summarize recent discoveries showing that autophagy also plays a critical role in stem cell maintenance and in a variety of cell differentiation processes. We also discuss a possible role for autophagy during cellular reprogramming and induced pluripotent stem (iPS) cell generation by taking advantage of ATP generation for chromatin remodeling enzyme activity and mitophagy. Finally, the significance of autophagy modulation is discussed in terms of augmenting efficiency of iPS cell generation and differentiation processes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available