Journal
STEM CELLS
Volume 32, Issue 1, Pages 26-34Publisher
WILEY
DOI: 10.1002/stem.1517
Keywords
Cellular therapy; Adult stem cells; Autologous stem cell transplantation; Clinical translation
Categories
Funding
- MIUR
- Italian Ministry of Health
- European Community
- Seventh Framework Program: OptiStem [HEALTHF52009223098]
- Seventh Framework Program: BioCOMET [HEALTHF42011278807]
- Seventh Framework Program: BioTrachea [NMP3SL2012280584]
- PRIN Program
- Regione Emilia-Romagna: area 1b
- Regione Emilia-Romagna: Regenerative Medicine
- Regione Emilia-Romagna: PORFESR 200713Tecnopolo
- Ricerca Finalizzata [RFASR2006344265]
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Recent breakthroughs in regenerative medicine have generated enthusiasm and many efforts to explore new therapeutic potentials of both somatic and pluripotent stem cells. About 30 years passed since a discovery of a method of producing a great number of human epidermal keratinocytes by cultivation from a small skin biopsy, many possibilities are now envisaged for therapeutic application of different cultured cell types. The importance of stem cell content was proven for many tissues or organs in different pathologies. Ocular burns cause depletion of limbal stem cells, which lead to corneal opacification and visual loss. Most of available treatments are palliative and focused on the relief of the devastating clinical picture. This review is focused on recent developments in cell-based therapy of limbal stem cell deficiency. All findings can provide support for improvement and standardization of the cure for this disabling disease. Stem Cells2014;32:26-34
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