Journal
STEM CELLS
Volume 30, Issue 12, Pages 2692-2699Publisher
WILEY
DOI: 10.1002/stem.1241
Keywords
Induced pluripotent stem cells; Mesenchymal stem cells; Allergy; Immunomodulation
Categories
Funding
- National Natural Science Grant of China [81071030, 81170896, 31270967, 81272062, 81273272, 81271055]
- Science and Technology Foundation of Guangdong Province, People's Republic of China [2011B031800243]
- Fundamental Research Funds for the Central Universities [09ykpy25]
- Industry Foundation of the Ministry of Health, China [201202005]
- Hong Kong Research Grant Council General Research Fund [HKU772510M]
- HKU Seed Funding Programme for Basic Research [201111159183]
- Theme-based Research Scheme [T12-705/11]
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We previously found that mesenchymal stem cells (MSCs) derived from human-induced pluripotent stem cells (iPSCs) exerted immunomodulatory effects on Th2-mediated allergic rhinitis in vitro. However, their contribution to the asthma and allergic rhinitis in animal models remains unclear. In this study, we developed a mouse model of ovalbumin (OVA)-induced allergic inflammation in both the upper and lower airways and evaluated the effects of the systemic administration of human iPSC-MSCs and bone marrow-derived MSCs (BM-MSCs) on allergic inflammation. Our results showed that treatments with both the iPSC-MSCs and BM-MSCs before the challenge phase protected the animals from the majority of allergy-specific pathological changes. This protection included an inhibition of inflammatory cell infiltration and mucus production in the lung, a reduction in eosinophil infiltration in the nose, and a decrease in inflammatory cell infiltration in both the bronchoalveolar and nasal lavage fluids. In addition, treatment with iPSC-MSCs or BM-MSCs before the challenge phase resulted in reduced serum levels of Th2 immunoglobulins (e.g., IgE) and decreased levels of Th2 cytokines including interleukin (IL)-4, IL-5, or IL-13 in the bronchoalveolar and/or nasal lavage fluids. Similar therapeutic effects were observed when the animals were pretreated with human iPSC-MSCs before the sensitization phase. These data suggest that iPSC-MSCs may be used as an alternative strategy to adult MSCs in the treatment of asthma and allergic rhinitis. Stem Cells 2012; 30: 2692-2699
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