Journal
STEM CELLS
Volume 31, Issue 1, Pages 8-11Publisher
WILEY
DOI: 10.1002/stem.1253
Keywords
Spermatogenic stem cell; Primordial germ cell; Progenitor cell; Syncytia; Stem cell niche; Chain fragmentation
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Funding
- NIH [5RO1HD10808-34, HD061665]
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The enormous number of sperms produced daily and over the lifetime of mammals requires a stable source of stem cells that give rise to progenitor cells that proceed through spermatogenesis. Spermatogenic stem cells develop from primitive germ cells that occupy the developing gonad. A transplantation assay was developed for the spermatogenic stem cells, and it remains the only functional measure of authentic stem cells in the testis. Somatic cells comprise a niche environment that is essential for the maintenance of stem cell activity. Dividing progenitor cells have intercellular bridges and form syncytia with 2, 4, 8, or 16 cells. Fragmentation of these syncytia may allow some progenitor cells to occupy niches and function as stem cells, but this notion requires further investigation. Spermatogenic stem cells can be maintained in culture and are influenced by a number of growth factors. Thus far, the ultimate differentiation of cultured stem cells into functional gametes has not been demonstrated with any efficiency and reproducibility. The ability to maintain spermatogenic stem cells in culture and to induce differentiation into haploid cells and sperm could have many important implications for human medicine. STEM CELLS 2013;31:8-11
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