Journal
STEM CELLS
Volume 29, Issue 6, Pages 920-927Publisher
WILEY
DOI: 10.1002/stem.645
Keywords
Mesenchymal stem cells; Diagnostic imaging; Neoplasm metastasis; Neoplasms; Disease models; Animal models
Categories
Funding
- NIH Tissue Engineering Resource Center [P41 EB002520]
- Susan Komen Breast Cancer Metastasis [BCTR0706887]
- Department of Defense [W81XWH-10-1-0086]
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Despite the decline in U. S. cancer incidence and mortality rates, cancer remains the number one cause of death for people under the age of 85 and one in four people in the U. S. will die of cancer, mainly because of metastasis. Recently, interest in mesenchymal stem cell (MSC) tumor-homing has led to inquires into: (a) why MSCs home to tumors, (b) what the inherent protumor and antitumor consequences are, and (c) how to best capitalize on MSC tumor-homing for cell-based diagnostics and therapy. Here, these questions are reviewed and method for addressing them using animal models and tracking methodologies (or, synonymously, detection methodologies) are discussed. First, MSCs in a regenerative and tumor-homing context are reviewed, followed by MSC delivery and genetic labeling methods for tissue model systems. Finally, the use of the nonoptical methods, magnetic resonance imaging, positron emission tomography, and single photon emission computed tomography, along with optical methods, fluorescence imaging and bioluminescent imaging, are reviewed related to tracking MSCs within disease model settings. The benefits and drawbacks of each detection method in animal models is reviewed along with the utility of each for therapeutic use. STEM CELLS 2011;29:920-927
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