Journal
STEM CELLS
Volume 29, Issue 5, Pages 749-754Publisher
WILEY
DOI: 10.1002/stem.629
Keywords
Adipose; Adipogenesis; Adult stem cells; Cellular therapy; Stem cell transplantation; Stromal cells; Clinical translation; Current Good Manufacturing Practices
Ask authors/readers for more resources
Subcutaneous fat has emerged as an alternative tissue source for stromal/stem cells in regenerative medicine. Over the past decade, international research efforts have established a wealth of basic science and preclinical evidence regarding the differentiation potential and regenerative properties of both freshly processed, heterogeneous stromal vascular fraction cells and culture expanded, relatively homogeneous adipose-derived stromal/stem cells. The stage has been set for clinicians to translate adipose-derived cells from the bench to the bedside; however, this process will involve development steps that fall outside of traditional hypothesis-driven, mechanism-based paradigm. This concise review examines the next stages of the development process for therapeutic applications of adipose-derived cells and highlights the current state of the art regarding clinical trials. It is recommended that the experiments addressing these issues be reported comprehensively in the peer-review literature. This transparency will accelerate the standardization and reproducibility of adipose-derived cell therapies with respect to their efficacy and safety. STEM CELLS 2011; 29: 749-754
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available