Journal
STEM CELLS
Volume 28, Issue 11, Pages 2084-2087Publisher
WILEY-BLACKWELL
DOI: 10.1002/stem.513
Keywords
Antibody; Blood-brain barrier; Cancer therapy; alpha-Carcinoembryonic antigen; CD3; Diabody; EGFR; HER2; Neural stem cells; Mesenchymal stem cells; scFv
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Monoclonal antibodies are important tools for cancer therapy, however, three factors limit their effectiveness: toxicity, poor tumor penetration, and inability to cross the blood-brain barrier. This review discusses the emerging field of stem cell-mediated antibody delivery and how this approach may improve antibody therapy of cancer by overcoming these obstacles. STEM CELLS 2010;28:2084-2087
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