Journal
STEM CELLS
Volume 28, Issue 9, Pages 1560-1567Publisher
WILEY
DOI: 10.1002/stem.491
Keywords
ARID3a; Multipotency; Embryonic stem cells; Reprogramming; Stem cell plasticity; Transcription factors
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Funding
- NIH [AI44215, AI64886, AI20069]
- Oklahoma Medical Research Foundation
- Marie Betzner Morrow Centennial Endowment
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B-cell regulator of immunoglobulin heavy chain transcription (Bright)/ARID3a, an A+T-rich interaction domain protein, was originally discovered in B lymphocyte lineage cells. However, expression patterns and high lethality levels in knockout mice suggested that it had additional functions. Three independent lines of evidence show that functional inhibition of Bright results in increased developmental plasticity. Bright-deficient cells from two mouse models expressed a number of pluripotency-associated gene products, expanded indefinitely, and spontaneously differentiated into cells of multiple lineages. Furthermore, direct knockdown of human Bright resulted in colonies capable of expressing multiple lineage markers. These data suggest that repression of this single molecule confers adult somatic cells with new developmental options. STEM CELLS 2010;28:1560-1567
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