Journal
STEM CELLS
Volume 27, Issue 1, Pages 40-48Publisher
WILEY
DOI: 10.1634/stemcells.2008-0493
Keywords
Glioblastoma; Tumor-initiating cells; SOX2 gene silencing; Tumorigenesis
Categories
Funding
- FIRC fellowship
- Ministero della Sanita
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- Fondazione Carige
- MIUR-PRIN
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Glioblastoma, the most aggressive cerebral tumor, is invariably lethal. Glioblastoma cells express several genes typical of normal neural stem cells. One of them, SOX2, is a master gene involved in sustaining self-renewal of several stem cells, in particular neural stem cells. To investigate its role in the aberrant growth of glioblastoma, we silenced SOX2 in freshly derived glioblastoma tumor-initiating cells (TICs). Our results indicate that SOX2 silenced glioblastoma TICs, despite the many mutations they have accumulated, stop proliferating and lose tumorigenicity in immunodeficient mice. SOX2 is then also fundamental for maintenance of the self-renewal capacity of neural stem cells when they have acquired cancer properties. SOX2, or its immediate downstream effectors, would then be an ideal target for glioblastoma therapy. STEM CELLS 2009; 27: 40-48
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