Journal
STEM CELLS
Volume 28, Issue 1, Pages 93-99Publisher
WILEY
DOI: 10.1002/stem.253
Keywords
embryonic stem cells; iPS cells; stem cell therapy; spinal cord
Categories
Funding
- Regional Government Health Department
- Spanish Ministry of Health
- Spanish Ministry of Science and Innovation [SAF2007-63193]
- La Marato [TV3 070330]
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Spinal cord injury (SCI) causes myelopathy, damage to white matter, and myelinated fiber tracts that carry sensation and motor signals to and from the brain. The gray matter damage causes segmental losses of interneurons and motoneurons and restricts therapeutic options. Recent advances in stem cell biology, neural injury, and repair, and the progress toward development of neuroprotective and regenerative interventions are the basis for increased optimism. This review summarizes the pathophysiological mechanisms following SCI and compares human embryonic, adult neural, and the induced pluripotent stem cell-based therapeutic strategies for SCI. STEMCELLS 2010; 28: 93
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