Journal
STEM CELLS
Volume 27, Issue 1, Pages 150-156Publisher
WILEY
DOI: 10.1634/stemcells.2008-0576
Keywords
Heterotopic ossification; Fibrodysplasia ossificans progressiva; Nse-BMP4; Macrophages
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Funding
- Center for Research in FOP
- Related Disorders of The University of Pennsylvania School of Medicine
- NIH [NS20013, NS20778]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS020778, R01NS020013] Funding Source: NIH RePORTER
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Heterotopic ossification (HO), the abnormal formation of true marrow-containing bone within extraskeletal soft tissues, is a serious bony disorder that may be either acquired or hereditary. We utilized an animal model of the genetic disorder fibrodysplasia ossificans progressiva to examine the cellular mechanisms underlying HO. We found that HO in these animals was triggered by soft tissue injuries and that the effects were mediated by macrophages. Spreading of HO beyond the initial injury site was mediated by an abnormal adaptive immune system. These observations suggest that dysregulation of local stem/progenitor cells could be a common cellular mechanism for typical HO irrespective of the signal initiating the bone formation. STEM CELLS 2009; 27: 150-156
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