Journal
STEM CELLS
Volume 26, Issue 1, Pages 173-181Publisher
WILEY
DOI: 10.1634/stemcells.2007-0293
Keywords
neural stem cells; c-Myb; ependymal cells; transcription factor; mice
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Funding
- Medical Research Council [G9818340B] Funding Source: researchfish
- Wellcome Trust Funding Source: Medline
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Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.
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