Journal
STEM CELL REVIEWS AND REPORTS
Volume 7, Issue 2, Pages 238-247Publisher
SPRINGER
DOI: 10.1007/s12015-010-9191-9
Keywords
Stem cells; Mammary gland; Niche; Label-retaining cells; Asymmetric DNA segregation; Parity identified mammary epithelial cells; Lobule progenitor; Ductal progenitor
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Any portion of the mouse mammary gland is capable of recapitulating a clonally derived complete and functional mammary tree upon transplantation into an epithelial divested mammary fat-pad of a recipient host. As such, it is an ideal model tissue for the study somatic stem cell function. This review will outline what is known regarding the function of stem/progenitor cells in the mouse mammary gland, including how progenitor populations can be functionally defined, the evidence for and potential role of selective DNA strand segregation, and the role of the niche in maintaining and controlling stem cell function.
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