Journal
STEM CELL REVIEWS
Volume 4, Issue 3, Pages 203-210Publisher
HUMANA PRESS INC
DOI: 10.1007/s12015-008-9021-5
Keywords
glioma; cancer stem cells; mouse models; Akt signaling
Categories
Funding
- Witmer foundation
- NIH [CA100688, RO1 CA099489]
- Federazione Italiana Ricerca Cancro (FIRC)
- Associazione Italiana per la Ricerca sul Cancro Funding Source: Custom
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Several recent reports have provided evidence that cancer is initiated by a rare fraction of cells called cancer stem cells which are multipotent, self-renewing subset of the tumor. However, several issues regarding the biology and techniques of isolating these cells from solid tumors remain to be clarified. In addition, experimental data supports two possibilities for glioma cell of origin. First, that stem cells or early progenitors are transformed and show variable differentiation of their progeny during tumor development. Second, that more differentiated glia are transformed by genetic events that lead to a loss of differentiation maintenance. In human gliomas, these two theories are not mutually exclusive. In this review we will summarize both theories, and highlight outstanding issues that remain to be resolved.
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