Journal
STEM CELL REVIEWS
Volume 4, Issue 2, Pages 89-99Publisher
HUMANA PRESS INC
DOI: 10.1007/s12015-008-9018-0
Keywords
VSEL; CXCR4; Oct-4; nanog; SSEA
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Funding
- NCI NIH HHS [R01 CA106281-01] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [R01CA106281] Funding Source: NIH RePORTER
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In this review, we discuss current views of the bone marrow (BM) stem cell (SC) compartment and present data showing that BM contains heterogeneous populations of hematopoietic (H)SCs and non-HSCs. These cells are variously described in the literature as: endothelial progenitor cells (EPCs); mesenchymal (M)SCs; multipotent adult progenitor cells (MAPCs); marrow-isolated adult multilineage inducible (MIAMI) cells; and multipotent adult (MA)SCs. In some cases, it is likely that similar or overlapping populations of primitive SCs in the BM detected using various experimental strategies were assigned different names. Recently, we purified rare CXC chemokine receptor 4 expressing (CXCR4(+)) small SCs from the murine BM that express markers characteristic for embryonic (E)SCs, epiblast (EP)SCs, and primordial germ cells (PGCs). We named these primitive cells very small embryonic-like (VSEL) SCs. Our data indicate that VSELs may differentiate into cells from all three germ layers.
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