Journal
STEM CELL REVIEWS AND REPORTS
Volume 5, Issue 1, Pages 66-71Publisher
SPRINGER
DOI: 10.1007/s12015-008-9047-8
Keywords
Cancer stem cell; Invasiveness; Isolation; Migration; Extracellular matrix
Funding
- National Basic Research Program of China 973 Program [2006CB708503]
- National Natural Science Foundation of China [30725035, 30700863]
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Cancer stem cells (CSCs) have multiple potentials in carcinogenesis and tumor progression. However, it is rather difficult to enrich and amplify CSCs either from tumor cell lines or even primary tumor tissues. Therefore, establishing new methodologies for isolation and enrichment based on the functional properties of CSCs is of great importance for studies on CSCs. According to the findings that CSCs possess more infiltrative capability as compared with their differentiated descendants, we propose a novel strategy based on heterogeneity of cancer cell invasiveness for isolation and enrichment of CSCs from committed cancer cell population. In addition, we hypothesize that existence of CSCs might be the real root of tumor invasion and metastasis.
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