Journal
STEM CELL RESEARCH
Volume 13, Issue 3, Pages 532-541Publisher
ELSEVIER
DOI: 10.1016/j.scr.2014.09.003
Keywords
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Funding
- National Institutes of Health (NIH) [F32 HL108570, AG032977, AG040019, U01MH098953, R01HL106302, K08 HL085143]
- Department of Cardiology at Boston Children's Hospital, Children's Cardiomyopathy Foundation
- Harold S. Geneen Charitable Trust Award Program
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Cardiomyocyte proliferation and progenitor differentiation are endogenous mechanisms of myocardial development. Cardiomyocytes continue to proliferate in mammals for part of post-natal development. In adult mammals under homeostatic conditions, cardiomyocytes proliferate at an extremely low rate. Because the mechanisms of cardiomyocyte generation provide potential targets for stimulating myocardial regeneration, a deep understanding is required for developing such strategies. We will discuss approaches for examining cardiomyocyte regeneration, review the specific advantages, challenges, and controversies, and recommend approaches for interpretation of results. We will also draw parallels between developmental and regenerative principles of these mechanisms and how they could be targeted for treating heart failure. (C) 2014 The Authors. Published by Elsevier B.V.
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