Journal
STATISTICS IN MEDICINE
Volume 27, Issue 27, Pages 5578-5585Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/sim.3383
Keywords
cluster randomized trial; common correlation model; cross-over; experimental design
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The cluster randomized cross-over design has been proposed in particular because it prevents an imbalance that may bring into question the internal validity of parallel group cluster trials. We derived a sample size formula for continuous outcomes that takes into account both the intraclass correlation coefficient (representing the clustering effect) and the interperiod correlation (induced by the cross-over design). Copyright (C) 2008 John Wiley & Sons, Ltd.
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