Journal
STATISTICS & PROBABILITY LETTERS
Volume 80, Issue 3-4, Pages 177-185Publisher
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DOI: 10.1016/j.spl.2009.10.004
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The article deals with an optimal response-adaptive design for allocating patients among two competing treatments in a phase III clinical trial. An optimal response-adaptive target is developed for a general class of response distributions subject to two clinically relevant constraints. Various theoretical and numerical properties of the proposed procedure are investigated and compared with some existing competitors. A data study is also included for the assessment of the proposed procedure in real situation. (C) 2009 Elsevier B.V. All rights reserved.
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