Journal
SPINAL CORD
Volume 51, Issue 1, Pages 2-9Publisher
SPRINGERNATURE
DOI: 10.1038/sc.2012.137
Keywords
spinal cord injury; clinical trials; neurological recovery
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After three decades of clinical research on interventions to improve neurological outcomes in persons with spinal cord injury (SCI), the promise of preclinical discovery has yet to be translated into a consensus standard of care treatment. Nonetheless, SCI researchers remain hopeful that advances in preclinical discovery coupled with improved clinical trial performance will yield effective restorative treatment. This historical review of key studies in SCI over the past 30 years illustrates the progress that has been achieved in establishing a high standard in the conduct of clinical research while providing important lessons for improving trial design, conduct and reporting. Through application of these lessons, the performance of SCI trials can be improved, thereby shortening the pathway to successful translation and the development of effective therapies. Spinal Cord (2013) 51, 2-9; doi: 10.1038/sc.2012.137; published online 20 November 2012
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