Journal
SPECTROSCOPY LETTERS
Volume 43, Issue 7-8, Pages 545-549Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/00387010.2010.510764
Keywords
bismuth; bismuth subsalicylate; EDTA titration; flame atomic absorption spectroscopy; method development; United States Pharmacopeia; UV-Vis spectroscopy
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Funding
- College of Science and Mathematics
- NSF [9950378, 0215892]
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Three different methods were developed and employed to analyze the concentration of bismuth subsalicylate in an oral liquid pharmaceutical suspension. These methods were UV-Visible spectroscopy utilizing the external calibration method and the standard addition method, flame atomic absorption spectroscopy, and complexometric titration with EDTA. All three methods were conducted within one 3-hr period by undergraduate students in analytical chemistry laboratory class settings and produced results within the allowable range of 90.0-110.0% as listed in the United States Pharmacopeia. Differences in sensitivity, precision, sample size, time, and reagent use between the three methods were observed.
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