Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 125, Issue -, Pages 440-448Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2014.01.086
Keywords
Thiosemicarbazone; Isatin moiety; CT-DNA binding; DNA cleavage; In vitro anti-proliferative activity
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Funding
- Malaysian Government
- Universiti Sains Malaysia [1001/PKIMIA/815067]
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New derivatives of thiosemicarbazone Schiff base with isatin moiety were synthesized L1-L6. The structures of these compounds were characterized based on the spectroscopic techniques. Compound L6 was further characterized by XRD single crystal. The interaction of these compounds with calf thymus (CT-DNA) exhibited high intrinsic binding constant (k(b) = 5.03-33.00 x 10(5) M-1) for L1-L3 and L5 and (6.14-9.47 x 10(4) M-1) for L4 and L6 which reflect intercalative activity of these compounds toward CT-DNA. This result was also confirmed by the viscosity data. The electrophoresis studies reveal the higher cleavage activity of L1-L3 than L4-L6. The in vitro anti-proliferative activity of these compounds against human colon cancer cell line (HCT 116) revealed that the synthesized compounds (L3, L6 and L2) exhibited good anticancer potency. (C) 2014 Elsevier B.V. All rights reserved.
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