Hg2+ mediated quinazoline ensemble for highly selective recognition of Cysteine

A fluorimetric sensor for Hg2+ ion and Cysteine based on quinazoline platform was designed and synthesized by one step reaction and characterized by using common spectroscopic methods. Time Dependent Density Functional Theory calculations shows that probe behaves as ON-OFF fluorescent quenching sensor via electron transfer/heavy atom effect. Receptor was found to exhibit selective fluorescence quenching behavior over the other competitive metal ions, and also the receptor-Hg2+ ensemble act as an efficient OFF-ON sensor for Cysteine. Moreover this sensor has also been successfully applied to detection of Hg2+ in natural water samples with good recovery. (C) 2013 Elsevier B.V. All rights reserved.