Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 115, Issue -, Pages 445-451Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2013.06.082
Keywords
Photodynamic therapy; Phthalocyanine; Water-soluble; CT DNA; Singlet oxygen
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Funding
- National Natural Science Foundation of China [20973093, 21201102]
- Natural Science Foundation of Jiangsu Higher Education Institutions of China [12KJB150015]
- Scientific Research Foundation of Nanjing Normal University [2011103XG0249]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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A novel 3-(4-methoxybenzylamino) propanoic acid substituted water-soluble zinc phthalocyanine (CNPcZn) was synthesized. The interaction between CNPcZn with calf thymus DNA (CT DNA) was studied using spectroscopic methods. The studies indicated that CNPcZn has strong affinity to CT DNA, and furthermore, CNZnPc showed excellent photodamaging activity to CT DNA. Above results indicated that such CNPcZn has great potential to be used as an effective photosensitizer in the field of photodynamic therapy. (C) 2013 Elsevier B.V. All rights reserved.
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