Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 107, Issue -, Pages 8-15Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2013.01.021
Keywords
5-Aminosalicylic acid; Spectral studies; Transition metal complexes; Thermal analyses; Biological activity
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The complexing behavior of mesalazine (5-aminosalicylic acid; 5-ASA) towards the transition metal ions namely, Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) have been examined by elemental analyses, magnetic measurements, electronic, IR and H-1 NMR. Thermal properties and decomposition kinetics of all complexes are investigated. The interpretation, mathematical analyses and evaluation of kinetic parameters of all thermal decomposition stages have been evaluated using Coats-Redfern equation. The free ligand and its metal complexes have been tested in vitro against Aspergillus fumigatus and Candida albicans fungi and Pseudomonas aeruginosa, Escherichia coli, Bacillis subtitles and Staphylococcus aureus bacteria in order to assess their antimicrobial potential. The results indicate that the metal complexes are also found to have more antimicrobial activity than the parent 5-ASA drug. (c) 2013 Elsevier B.V. All rights reserved.
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