Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 108, Issue -, Pages 251-255Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2013.02.003
Keywords
PAMAM-C-12 25%; Curcumin; Fluorescence; Binding mode; Binding sites
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Funding
- Natural Science Foundation of Jiangsu Province [BK2011422, BK2012671]
- Educational Bureau [11KJB150019]
- Jiangsu Fundament of Qilan Project
- Scientific Foundation of Yancheng Teachers University
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The interactions between PAMAM-C-12 25% and curcumin were studied by UV/vis, fluorescence spectroscopy, and molecular modeling methods. The experimental results showed that the formation of PAMAM-C-12 25%@curcumin non-covalent adduct induced the fluorescence quenching of PAMAM-C-12 25%; Curcumin entered the interface of PAMAM-C-12 25% with mainly five classes of binding sites by hydrophobic, hydrogen bonds, and van der Waals forces interactions. The bigger values of binding constants indicated that PAMAM-C-12 25% hold the curcumin tightly. (c) 2013 Elsevier B.V. All rights reserved.
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