Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 94, Issue -, Pages 143-151Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2012.03.077
Keywords
Antibacterial; Complexes; Molecular modeling; Powder XRD; Schiff base; Spectra
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Funding
- Council of Scientific and industrial Research (CSIR)
- University Grants Commission (UGC) New Delhi, India
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Schiff bases derived from 2-nitrobenzaldehyde with amino acids (glycine, methionine) and their Co(II), Ni(II) and Cu(II) complexes have been synthesized and characterized by various physico-chemical techniques. From spectral studies, it has been concluded that the ligands acts as bidentate molecule, coordinates metal through azomethine nitrogen and carboxylate oxygen. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML2 complexes. X-ray powder diffraction helps to determine the cell parameters of the complexes. Molecular structure of the complexes has been optimized by MM2 calculations and suggests a square planar geometry. The ligands and their metal complexes have been tested in vitro against Streptococcus, Staph, Staphylococcus aureus and Escherchia coil bacteria in order to assess their antibacterial potential. The results indicate that the biological activity increases on complexation. (C) 2012 Elsevier B.V. All rights reserved.
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