Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 77, Issue 4, Pages 895-901Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2010.08.065
Keywords
Bovine serum albumin (BSA); Sonocatalytic damage; Metronidazole (MTZ); Nano-sized ZnO; Ultrasound
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Funding
- National Natural Science Foundation of China
- Liaoning Province Natural Science Foundation of Education Department
- Liaoning Province Natural Science Foundation of Science and Technology Department
- Liaoning University ldquo
- 211rdquo
- Engineering Construction Foundation
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The previous work proved that the bovine serum albumin (BSA) could be damaged under the combined action of ultrasonic irradiation and ZnO. In this work, the assisted sonocatalytic damage of BSA using metronidazole (MTZ) as a sensitizer was further investigated by means of UV-vis and fluorescence spectra. The results indicated that the adding of MTZ could obviously promote the sonocatalytic damage of BSA under ultrasonic irradiation in the presence of nano-sized ZnO powder. Furthermore, it was found that the damage degree of BSA was aggravated by some influencing factors except ionic kind and strength. In addition, the damage site of BSA was also studied with synchronous fluorescence technology. It was found that the damage site was mainly at tryptophan (Trp) residue. (C) 2010 Elsevier B.V. All rights reserved.
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