Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 72, Issue 3, Pages 577-581Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2008.10.044
Keywords
Silver nanoparticle; Nucleic acids; CPB; Absorption spectrum; Resonance light scattering spectrum; Genotoxicity
Categories
Funding
- NSFC [20607011, 20875055, NCET-06-0582]
- Young Scientists and Key Science-Technology Project in Shandong Province [2007BS08005, 2008GG10006012]
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The environmental genotoxic behavior of silver nanoparticles (nanoAg) combined with the detergent cetylpyridine bromide (CPB) was examined in vitro. The experimental results showed that the genotoxicity of nanoAg itself is weak, but nanoAg shows obvious genotoxicity after combined with CPB. The combined materials have a strong coeffect on calf thymus DNA (ctDNA) at a concentration of 3.3 x 10(-6) gmL(-1) nanoAg and 6.0 x 10(-6) mol L-1 CPB. After the addition of ctDNA to the nanoAg-CPB system, the particles are scattered and the diameter decreases, which indirectly reveal that nanoAg-CPB has genotoxicity. (c) 2008 Elsevier B.V. All rights reserved.
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