Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 72, Issue 4, Pages 789-795Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2008.11.020
Keywords
Charge transfer; Spectrokinetic; Ketoconazole; Povidone; Iodine and Solvent effect
Categories
Funding
- University Grants Commission, New Delhi
- Rajiv Gandhi National Fellowship Scheme
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The interaction between ketoconazole and povidone drugs with iodine was found to proceed through initial formation of a charge transfer (CT) complex as an intermediate. The stoichiometry of the complex was found to be 1:1 in the case of povidone-iodine system and 1:2 in the case of ketoconazole-iodine system and the same was confirmed by thermal (TGA/DSC) Studies. The formation of I-3(-) species was confirmed by electronic and laser Raman spectra. The three peaks appeared in Raman spectra, of the isolated adducts corresponds to nu(as)(I-I), nu(s)(I-I) and delta(I-3(-)), confirmed the presence of asymmetric I-3 ion. The rate of the interaction has been measured as a function of time and solvent. The pseudo-first-order rate constants at various temperatures for the interactions were measured and the activation parameters (Delta G(#), Delta S-# and Delta H-#) were computed. Based on the spectral and spectrokinetic evidences a mechanism involving the formation of a polar intermediate and its conversion to the final product has been proposed and discussed. (C) 2008 Elsevier B.V. All rights reserved.
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