Assembly of an unprecedented metal-pipemidic acid complex modifying octamolybdates containing like DNA spiral chain

By introducing antibacterial drugs pipemidic acid into the octamolybdates, an unprecedented compound, [Zn(PPA)(2)(H2O)](2)center dot[Mo8O26]center dot 3.5H(2)O (1) (PPA = pipemidic acid), has been synthesized and characterized by routine physical methods. Single-crystal X-ray diffraction analysis reveals that the title compound contains the right- and left-double-stranded like DNA helical chains, which are assembled together via sharing the beta-Mo-8 clusters forming the fascinating double intertwined inverted helices. The result of the antitumor activities shows that the title compound possesses higher antitumor activity and selectivity. (C) 2014 Elsevier Masson SAS. All rights reserved.