Journal
ADVANCED HEALTHCARE MATERIALS
Volume 5, Issue 4, Pages 449-456Publisher
WILEY
DOI: 10.1002/adhm.201500700
Keywords
antibacterial surfaces; bacterial release; pH-responsive; silicon nanowire arrays
Funding
- National Natural Science Foundation of China [21334004, 21404076]
- National Science Fund for Distinguished Young Scholars [21125418]
- Natural Science Foundation of Jiangsu Province [BK20140316]
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For various human healthcare and industrial applications, endowing surfaces with the capability to not only efficiently kill bacteria but also release dead bacteria in a rapid and repeatable fashion is a promising but challenging effort. In this work, the synergistic effects of combining stimuli-responsive polymers and nanomaterials with unique topographies to achieve smart antibacterial surfaces with on-demand switchable functionalities are explored. Silicon nanowire arrays are modified with a pH-responsive polymer, poly(methacrylic acid), which serves as both a dynamic reservoir for the controllable loading and release of a natural antimicrobial lysozyme and a self-cleaning platform for the release of dead bacteria and the reloading of new lysozyme for repeatable applications. The functionality of the surface can be simply switched via step-wise modification of the environmental pH and can be effectively maintained after several kill-release cycles. These results offer a new methodology for the engineering of surfaces with switchable functionalities for a variety of practical applications in the biomedical and biotechnology fields.
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