Journal
ADVANCED HEALTHCARE MATERIALS
Volume 5, Issue 4, Pages 467-473Publisher
WILEY
DOI: 10.1002/adhm.201500827
Keywords
anticancer phototherapy; block copolymers; drug delivery; metallopolymers; self-assembly; stimuli-responsive
Funding
- CSC program
- Deutsche Forschungsgemeinschaft (DFG) [WU 787/2-1, SPP1313, MA 3271/3-1, SFB1066]
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The use of self-assembled nanostructures consisting of red-light-responsive Ru(II)-containing block copolymers (BCPs) for anticancer phototherapy is demonstrated. Three Ru-containing BCPs with different molecular weights are synthesized. Each BCP contains a hydrophilic poly(ethylene glycol) block and an Ru-containing block. In the Ru-containing block, more than half of the side chains are coordinated with [Ru(2,2:6,2-terpyridine)(2,2-biquinoline)](2+), resulting in more than 40 wt% Ru complex in the BCPs. The Ru complex acts as both a red-light-cleavable moiety and a photoactivated prodrug. Depending on their molecular weights, the BCPs assemble into micelles, vesicles, and large compound micelles. All of the BCP assemblies are taken up by cancer cells. Red-light irradiation releases the Ru complex and generates singlet oxygen (O-1(2)) in cancer cells. The released Ru complex and O-1(2) inhibit the growth of cancer cells. Among the three BCP assemblies, the BCP micelle exhibits the most efficient cellular uptake and best anticancer performance.
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