Journal
ADVANCED HEALTHCARE MATERIALS
Volume 4, Issue 16, Pages 2557-2586Publisher
WILEY
DOI: 10.1002/adhm.201500402
Keywords
-
Funding
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Agency for Science, Technology and Research, Singapore)
- Scientific and Technological Research Council of Turkey (TUBITAK) [113T045]
- TUBITAK BIDEB fellowship
- Turkish Academy of Sciences Distinguished Young Scientist Award (TUBA-GEBIP)
- Marie Curie Industry-Initial Training Network (ITN)
- Greek Secretariat for Research and Technology, ARISTEIA II Excellence Grant [3941]
- European Social Fund and National Funds
Ask authors/readers for more resources
Self-assembling proteins and peptides are increasingly gaining interest for potential use as scaffolds in tissue engineering applications. They self-organize from basic building blocks under mild conditions into supramolecular structures, mimicking the native extracellular matrix. Their properties can be easily tuned through changes at the sequence level. Moreover, they can be produced in sufficient quantities with chemical synthesis or recombinant technologies to allow them to address homogeneity and standardization issues required for applications. Here. recent advances in self-assembling proteins, peptides, and peptide amphiphiles that form scaffolds suitable for tissue engineering are reviewed. The focus is on a variety of motifs, ranging from minimalistic dipeptides, simplistic ultrashort aliphatic peptides, and peptide amphiphiles to large recombinamer proteins. Special emphasis is placed on the rational design of self-assembling motifs and biofunctionalization strategies to influence cell behavior and modulate scaffold stability. Perspectives for combination of these bottom-up designer strategies with traditional top-down biofabrication techniques for new generations of tissue engineering scaffolds are highlighted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available