Journal
ADVANCED HEALTHCARE MATERIALS
Volume 4, Issue 8, Pages 1134-1151Publisher
WILEY
DOI: 10.1002/adhm.201500002
Keywords
biomedical textiles; implants; devices; silk-based biomaterials; medical applications; surface modifications
Funding
- National Natural Science Foundation of China (NSFC) [51273138]
- National Institutes of Health [P41 EB002520]
- State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University [LK1421]
- Guangdong Provincial Department of Science and Technology [2012B050800002]
- Natural Science Foundation for Young Scholars of Soochow University
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Biomedical textiles and fiber-based implants (BTFIs) have been in routine clinical use to facilitate healing for nearly five decades. Amongst the variety of biomaterials used, silk-based biomaterials (SBBs) have been widely used clinically viz. sutures for centuries and are being increasingly recognized as a prospective material for biomedical textiles. The ease of processing, controllable degradability, remarkable mechanical properties and biocompatibility have prompted the use of SBBs for various BTFIs for extracorporeal implants, soft tissue repair, healthcare/hygiene products and related needs. The present Review focuses on BTFIs from the perspective of types and physical and biological properties, and this discussion is followed with an examination of the advantages and limitations of BTFIs from SBBs. The Review covers progress in surface coatings, physical and chemical modifications of SBBs for BTFIs and identifies future needs and opportunities for the further development for BTFIs using SBBs.
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