Journal
SOFT MATTER
Volume 9, Issue 39, Pages 9342-9351Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sm50700a
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- National Research Council Canada (NRC)
- Canada Foundation for Innovation (CFI)
- Ontario Ministry of Economic Development and Innovation
- NSERC Undergraduate Research Awards (USRA)
- Province of Ontario
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The molecular in-plane and out-of-plane structure of dimyristoylphosphatidylcholine (DMPC) membranes containing up to 60 mol% of cholesterol was studied using X-ray diffraction. Up to 37.5 mol% cholesterol could be dissolved in the membranes, resulting in a disordered lateral membrane structure. Highly ordered cholesterol structures were observed at cholesterol concentrations of more than 40 mol% cholesterol. These structures were characterized as immiscible cholesterol plaques, i.e., bilayers of cholesterol molecules coexisting with the lipid bilayer. The cholesterol molecules were found to form a monoclinic structure at 40 mol% cholesterol, which transformed into a triclinic arrangement at the highest concentration of 60 mol%. Monoclinic and triclinic structures were found to coexist at cholesterol concentrations between 50 and 55 mol%.
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