Journal
SOFT MATTER
Volume 9, Issue 1, Pages 82-89Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sm26996a
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Funding
- National Institutes of Health [HHSN268201000046C]
- National Science Foundation through the MRSEC program [DMR-1121053]
- Wenner-Gren foundation
- Bengt Lundqvist foundation
- STINT
- Karolinska Institutet
- Jeanssons Foundation
- Ake Wibergs Foundation
- Eva and Axel Wallstroms Foundation
- Percy Falks Fundation
- Carl Bennet AB
- Swedish Research Council (VR) [2009-3259, 2011-3720]
- Swedish Medical Nanoscience Center
- Swedish Governmental Agency for Innovation Systems (Vinnova)
- Direct For Mathematical & Physical Scien [0843934] Funding Source: National Science Foundation
- Division Of Materials Research [0843934] Funding Source: National Science Foundation
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Histamine functionalized poly(allyl glycidyl ether)-b-poly(ethylene glycol)-b-poly(allyl glycidyl ether) (PAGE-PEO-PAGE) triblock copolymers represent a new class of physically cross-linked, pH-responsive hydrogels with significant potential for biomedical applications. These telechelic triblock copolymers exhibited abrupt and reversible hydrogelation above pH 7.0 due to a hydrophilic/hydrophobic transition of the histamine units to form a network of hydrophobic domains bridged by a hydrophilic PEO matrix. These hydrophobic domains displayed improved ordering upon increasing pH and self-assembled into a body centered cubic lattice at pH 8.0, while at lower concentrations formed well-defined micelles. Significantly, all materials were found to be non-toxic when evaluated on three different cell lines and suggests a range of medical and biomedical applications.
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