Journal
SOFT MATTER
Volume 9, Issue 16, Pages 4150-4159Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3sm00066d
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Funding
- National Natural Science Foundation of China [21136006]
- National Basic Research Program of China [2009CB623407]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1163]
- National High Technology Research and Development Program (863 Program) [2012AA021403]
- State Key Laboratory of Polymer Materials Engineering (Sichuan University)
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Hydrogel-based hollow microcapsules with good monodispersity and repeated glucose-response under physiological temperature and glucose concentration conditions have been fabricated by a simple emulsion-template approach. Double emulsions from microfluidic devices are used as templates to synthesize the monodisperse glucose-responsive microcapsules. In the poly(N-isopropylacrylamide-co-3-aminophenylboronic acid-co-acrylic acid) (P(NIPAM-co-AAPBA-co-AAc)) hydrogel shell of the microcapsules, the thermo-responsive PNIPAM network and the glucose-responsive AAPBA moiety are respectively used for actuation and glucose response, and the AAc moiety is used for adjusting the volume phase transition temperature of the shell. Glucose-responsive microcapsules prepared with 2.4 mol% AAc exhibit reversible and repeated swelling/shrinking response to glucose concentration changes within the physiological blood glucose concentration range (0.4-4.5 g L-1) at 37 degrees C. Rhodamine B and fluorescein-isothiocyanate-labeled insulin are used as model molecules and model drugs to demonstrate the potential application of the microcapsules for glucose-responsive controlled release. The microcapsules provide a promising and feasible model for developing glucose-responsive sensors and self-regulated delivery systems for diabetes and cancer therapy. Moreover, the microfluidic fabrication approach and research results presented here provide valuable guidance for the design and fabrication of monodisperse glucose-responsive microcapsules.
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