The emerging role of hydrogen bond interactions in polyglutamine structure, stability and association

Polyglutamine regions in proteins have been associated with protein aggregation and the development of serious neurodegenerative diseases. Using a bottom-up approach, the molecular properties of glutamine and single polyglutamine chains can be understood, providing a promising route to uncover the mechanisms of polyglutamine-related protein aggregation. In this article we highlight recent advances in the study of both glutamine and polyglutamine using novel biophysical tools. A recurring theme in these studies is the importance of hydrogen bonding in driving glutamine association.