Journal
SOFT MATTER
Volume 8, Issue 40, Pages 10233-10237Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sm26566d
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Funding
- National Science Foundation [DMR-0643226, DMR-0906815]
- National Institutes of Health [NIDCD: 3R01DC008965-03S2]
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Block copolymer micelles (BCMs) were prepared from amphiphilic diblock copolymers of poly(n-butyl acrylate) and poly(acrylic acid) partially modified with 2-hydroxyethyl acrylate. Radical polymerization of acrylamide in the presence of micellar crosslinkers gave rise to elastomeric hydrogels (BCM-PAAm) whose mechanical properties can be tuned by varying the BCM composition. Transmission electron microscopy (TEM) imaging revealed stretch-induced, reversible micelle deformation in BCM-PAAm gels. A model hydrophobic drug, pyrene, loaded into the micelle core prior to the formation of BCM-PAAm gels, was dynamically released in response to externally applied mechanical forces. The BCM-cross-linked hydrogels with combined strength and force-modulated drug release are attractive candidates for the repair and regeneration of mechanically active tissues.
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