Journal
SOFT MATTER
Volume 8, Issue 13, Pages 3665-3672Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sm25060h
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Funding
- National Natural Science Foundation of China [21074152, 21104099, 20874116]
- Education Ministry in China [20090171110023]
- Key Project of Scientific and Technical Innovation for Universities in Guangdong Province, China [cxzd1102]
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Novel supramolecular hydrogel/micelle composites were designed for the co-encapsulation and prolonged release of camptothecin (CPT) and granulocyte colony-stimulating factor (G-CSF). For this purpose, heparin-conjugated Pluronic F-127 (Hep-F-127) was synthesized by a click reaction and then used to self-assemble the micelles with their hydrophobic cores loaded with CPT and hydrophilic shells complexed with G-CSF. By mixing alpha-cyclodextrin (alpha-CD) and CPT-loaded Hep-F-127 micelle/G-CSF complexes in an aqueous system, the supramolecular hydrogel/micelle composite with good injectability could be formed under mild conditions. For the co-encapsulated CPT and G-CSF, they could maintain their biological activity and exhibit a more prolonged release when compared to CPT-loaded Hep-F-127 micelles/G-CSF complexes. Moreover, the gelation properties and drug release profiles could by tuned by alpha-CD amount.
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