Journal
SOFT MATTER
Volume 8, Issue 22, Pages 6033-6038Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2sm25274k
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Funding
- National Natural Science Foundation of China [21074078, 20974074]
- Natural Science Foundation of Jiangsu Province [BK20110045]
- Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices (Soochow University)
- China Scholarship Council
- Innovative Graduate Research Program of Jiangsu Province [CX09B_021Z]
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In situ forming hydrogels allow the modulation of physicochemical properties and are providing new opportunities for biomedical applications. Here, the preparation and characterization of a series of rapidly in situ forming and pH-responsive hydrogels with different crosslinking degrees are reported, which were achieved by accelerated free radical copolymerization of polyphosphoester-based macrocrosslinker and 2-(dimethylamino)ethyl methacrylate (DMAEMA) monomer. The hydrogel formation can be completed very quickly under mild conditions, ranging from several to tens of minutes with varying concentrations of components. The polyphosphoester-based macrocrosslinker was synthesized via a combination of ring-opening polymerization and post-polymerization modification, and it was characterized by H-1 NMR, P-31 NMR, and GPC measurements. The sol-gel transition was monitored by dynamic time sweep rheological analysis. Moreover, the swelling kinetics, interior morphology, pH-responsive property, in vitro cytotoxicity and drug release of these hydrogels were characterized. The results indicate that these hydrogels show great potential as injectable drug delivery system.
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