Journal
SOFT MATTER
Volume 7, Issue 10, Pages 4821-4827Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0sm01393e
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Funding
- National Basic Research Program (973 Program) of China [2009CB623407]
- National Natural Science Foundation of China [20825622, 20906064, 20990220, 21036002, 21076127]
- Ministry of Education of China [200806100038]
- Sichuan Youth Science and Technology Foundation [08ZQ026-042]
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Monodisperse core-shell microcapsules based on crosslinked chitosan membrane with acid-triggered burst release properties are successfully developed. The microcapsules are fabricated from double emulsion precursors that are prepared with a microfluidic approach. In neutral medium (pH 7.1), the microcapsules maintain a good spherical shape and structural integrity; while, in acidic medium (pH 1.5 similar to 4.7), the microcapsules decompose rapidly and release the encapsulated contents completely in short periods varying from 39 s to 22 min. The acid-triggered burst release pattern from the proposed chitosan microcapsules may make them capable for stomach-specific drug delivery systems with quick and complete release characteristics in a controllable pH-responsive manner.
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