Journal
SOFT MATTER
Volume 7, Issue 11, Pages 5417-5422Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1sm05324h
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Funding
- European Commission [NMP-2004-SME-3.4.4.6]
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A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion.
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