Journal
SOFT MATTER
Volume 6, Issue 17, Pages 4001-4009Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c000190b
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Funding
- Danish Agency for Science, Technology and Innovation [2106-08-0081, 274-08-0534]
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This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery.
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