Journal
SOFT MATTER
Volume 6, Issue 6, Pages 1073-1080Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b922341j
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About six years ago, almost simultaneously, three independent groups reported the synthesis of a novel class of dendritic molecules. These molecules were equipped with a focal trigger; reaction at the trigger initiated the fragmentation of the dendrimer to its building blocks in a domino-like manner with consequent release of at least two tail-units. We termed these molecules self-immolative dendrimers and demonstrated their distinctive ability to achieve molecular amplification of the initial triggering signal. The unique amplification effect obtained by self-immolative dendrimers is useful in the fields of drug delivery systems and diagnostic applications. This highlight summarizes the design, function, and applications of this unique class of molecules.
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