Journal
ACS MACRO LETTERS
Volume 5, Issue 1, Pages 14-19Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.5b00729
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Funding
- National Science Foundation [CHE-1263087]
- Kent State University
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3D biodegradable and highly regular foamlike cell scaffolds based on biocompatible side-chain liquid crystal elastomers have been prepared. Scaffolds with a primary porosity characterized by spatially interlaced, interconnected microchannels or an additional secondary porosity featuring interconnected microchannel networks define the novel elastomeric scaffolds. The macroscale morphology of the dual porosity 3D scaffold resembles vascular networks observed in tissue. 3D elastomer foams show four times higher cell proliferation capability compared to conventional porous templated films and within the channels guide spontaneous cell alignment enabling the possibility of tissue construct fabrication toward more clinically complex environments.
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