Journal
ACS MACRO LETTERS
Volume 5, Issue 1, Pages 60-63Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.5b00765
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Funding
- National Natural Science Foundation of China [21534008, 51322303, 51573110]
- State Key Laboratory of Polymer Materials Engineering [sklpme2014-3-01]
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Mesoporous silica nanoparticles (MSNs) exhibit significant advantages for efficient drug/gene delivery but it is hard for simple MSNs to deliver the loaded drug to the target sites of disease. Considering that there are some well-known pH differences in the body, it is a useful strategy to modify the exterior surface of MSNs with stimuli-responsive gatekeepers to realize open close transformation of their mesopores. In this work, multifunctional pH-sensitive MSNs were designed with mixed polymeric coatings, that is, poly(ethylene glycol) (PEG) as a dispersity-enhancer and poly(2-(pentamethyleneimino)ethyl methacrylate) (PPEMA) as an ultra-pH-sensitive gatekeeper. Enhanced dispersity, high drug loading capacity, long-circulation time, pH-triggered targeting, and better cellular uptake of the multifunctional MSNs make them potential candidates for pH-sensitive drug delivery such as tumor therapy.
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